CJC-1295 no DAC 5mg

CJC-1295 no DAC Structure

Source: pubchem

For Research Use Only – Not for Human or Veterinary Use

Product Summary

CJC-1295 no DAC (also known as Modified GRF (1-29), “mod GRF” or tetrasubstituted GHRH(1-29)) is a 29-amino-acid analogue of growth-hormone-releasing hormone engineered for improved stability versus native GHRH(1-29)/sermorelin. The “no DAC” form retains four stabilizing substitutions at positions 2, 8, 15, 27 but does not include the albumin-binding Drug Affinity Complex (DAC) found on CJC-1295 with DAC. These substitutions increase resistance to enzymatic cleavage and extend peptide half-life relative to unmodified GRF(1-29).

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Key Details

Molecular Formula: C152H252N44O42

Molecular Weight: 3367.9 g/mol

CAS Number:863288-34-0

Potential Research Applications

1. GH/IGF-1 Axis Physiology
   • Characterize GHRH-receptor activation, pulsatile GH release, and downstream IGF-1 responses in pituitary systems and rodent models.
2. Comparative Pharmacology
   • Compare stability and signaling of CJC-1295 no DAC vs. native GRF(1-29)/sermorelin and CJC-1295 with DAC to delineate the contribution of tetrasubstitution and albumin-binding chemistry.
3. Signal-Transduction Mapping
   • Map cAMP/PKA and PI3K/Akt cascades following GHRH-R engagement; evaluate cross-talk with somatostatin and GHSR pathways.
4. Bioanalytical Method Development
   • Use as a reference analyte for LC-HRMS/MS method optimization and proficiency testing in peptide detection workflows (sports-doping and clinical-research labs).

Safety and Compliance

1. Research Use Only
   • CJC-1295 no DAC 5 mg is intended exclusively for laboratory research and pre-clinical experimentation. Do not administer to humans or animals.
2. Regulatory Status
   • This reagent has not been evaluated or authorized by the FDA, EMA, PMDA, or other authorities. Possession and use are permitted only under rules applicable to investigational laboratory chemicals.
3. Liability
   • Supplier and manufacturer disclaim all warranties and accept no responsibility for injury, loss, or regulatory action arising from misuse. End-users are responsible for compliant storage (≤ –20 °C; protect from light/moisture), PPE, and disposal per institutional biosafety procedures.

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Disclaimer

All information herein is provided solely for educational and research purposes. CJC-1295 no DAC 5 mg is not licensed for therapeutic, diagnostic, or nutritional use in humans or animals. Users must ensure that all handling and experimentation comply with applicable laws, regulations, and institutional guidelines.