CJC-1295 no DAC Structure
For Research Use Only – Not for Human or Veterinary Use
Product Summary
CJC-1295 no DAC (also known as Modified GRF (1-29), “mod GRF” or tetrasubstituted GHRH(1-29)) is a 29-amino-acid analogue of growth-hormone-releasing hormone engineered for improved stability versus native GHRH(1-29)/sermorelin. The “no DAC” form retains four stabilizing substitutions at positions 2, 8, 15, 27 but does not include the albumin-binding Drug Affinity Complex (DAC) found on CJC-1295 with DAC. These substitutions increase resistance to enzymatic cleavage and extend peptide half-life relative to unmodified GRF(1-29).
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Key Details
Molecular Formula: C152H252N44O42
Molecular Weight: 3367.9 g/mol
CAS Number:863288-34-0
Potential Research Applications
- GH/IGF-1 Axis Physiology
- Characterize GHRH-receptor activation, pulsatile GH release, and downstream IGF-1 responses in pituitary systems and rodent models.
- Comparative Pharmacology
- Compare stability and signaling of CJC-1295 no DAC vs. native GRF(1-29)/sermorelin and CJC-1295 with DAC to delineate the contribution of tetrasubstitution and albumin-binding chemistry.
- Signal-Transduction Mapping
- Map cAMP/PKA and PI3K/Akt cascades following GHRH-R engagement; evaluate cross-talk with somatostatin and GHSR pathways.
- Bioanalytical Method Development
- Use as a reference analyte for LC-HRMS/MS method optimization and proficiency testing in peptide detection workflows (sports-doping and clinical-research labs).
Safety and Compliance
- Research Use Only
- CJC-1295 no DAC 5 mg is intended exclusively for laboratory research and pre-clinical experimentation. Do not administer to humans or animals.
- Regulatory Status
- This reagent has not been evaluated or authorized by the FDA, EMA, PMDA, or other authorities. Possession and use are permitted only under rules applicable to investigational laboratory chemicals.
- Liability
- Supplier and manufacturer disclaim all warranties and accept no responsibility for injury, loss, or regulatory action arising from misuse. End-users are responsible for compliant storage (≤ –20 °C; protect from light/moisture), PPE, and disposal per institutional biosafety procedures.
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Disclaimer
All information herein is provided solely for educational and research purposes. CJC-1295 no DAC 5 mg is not licensed for therapeutic, diagnostic, or nutritional use in humans or animals. Users must ensure that all handling and experimentation comply with applicable laws, regulations, and institutional guidelines.
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